Not at home with shy friendless person (7)
I believe the answer is:
outcast
'friendless person' is the definition.
The answer and definition can be both people as well as being singular nouns.
Perhaps there's an association between them I don't understand?
'not at home with shy' is the wordplay.
'not at home' becomes 'out' (out can mean away from home).
'with' is a charade indicator (letters next to each other).
'shy' becomes 'cast' (I've seen this before).
'out'+'cast'='OUTCAST'
Can you help me to learn more?
(Other definitions for outcast that I've seen before include "Pariah, one rejected by society" , "vagabond" , "Pariah, leper" , "One rejected by group" , "untouchable" .)