Not at home with shy rejected person (7)
I believe the answer is:
outcast
'rejected person' is the definition.
(I've seen this before)
'not at home with shy' is the wordplay.
'not at home' becomes 'out' (out can mean away from home).
'with' says to put letters next to each other.
'shy' becomes 'cast' (both can mean to throw).
'out'+'cast'='OUTCAST'
(Other definitions for outcast that I've seen before include "Role of Ishmael" , "untouchable" , "Displaced person" , "Rejected individual" , "One rejected by group" .)