Not the only one to take a leading part from actors (2-4)

I believe the answer is:

co-star

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'not the only one to take a leading part' is the definition.
I can't judge whether this defines the answer.

'from actors' is the wordplay.
'from' indicates anagramming the letters (from the letters).
'actors' with letters rearranged gives 'CO-STAR'.

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(Other definitions for co-star that I've seen before include "One with joint top billing" , "Fellow leading actor" , "One of joint leads" , "Joint main actor" , "Actor sharing top billing" .)

I've seen this clue in The Globe and Mail.

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