Note first pair of traders coming in to target Irish location (6)
I believe the answer is:
antrim
'irish location' is the definition.
(Irish county)
'note first pair of traders coming in to target' is the wordplay.
'note first' becomes 'n' (tst letter of 'note').
'pair of traders' becomes 'tr' (I can't explain this - if you can you should believe this answer much more).
'coming in to' indicates putting letters inside.
'target' becomes 'aim' (synonyms).
'n'+'tr'='ntr'
'ntr' inserted inside 'aim' is 'ANTRIM'.
(Other definitions for antrim that I've seen before include "Giant's Causeway county" , "N Ireland county of green glens" , "Part of Ireland" , "County in Ireland's north-east" , "town in Ireland" .)