Nothing disturbs bees like being overweight (5)
I believe the answer is:
obese
'being overweight' is the definition.
(I've seen this before)
'nothing disturbs bees' is the wordplay.
'nothing' becomes 'O' (O resembles 0).
'disturbs' indicates an anagram (I've seen 'disturbed' mean this (the order of letters is disturbed)).
'bees' is an anagram of 'bese'.
'o'+'bese'='OBESE'
'like' acts as a link.
(Other definitions for obese that I've seen before include "Stout" , "Roly-poly" , "Morbidly overweight" , "Enormously portly" , "having generous corporation" .)