Nothing left in safe? (3,5)
I believe the answer is:
all right
I believe this is a double definition.
'nothing left' is the first definition.
(I've seen this before)
'safe?' is the second definition.
(all right means safe or secure)
'in' is the link.
(Other definitions for all right that I've seen before include "Of acceptable quality" , "none left" , "Nothing left" , "Fair enough" , "Satisfactory; allowable" .)