Nothing stupid about university’s reproach (5)
I believe the answer is:
odium
'reproach' is the definition.
(I've seen this before)
'nothing stupid about university's' is the wordplay.
'nothing' becomes 'O' (looks like zero - 0).
'stupid' becomes 'dim' (similar in meaning).
'about' means one lot of letters goes inside another.
'university' becomes 'U' (abbreviation for university).
'dim' enclosing 'u' is 'dium'.
'o'+'dium'='ODIUM'
(Other definitions for odium that I've seen before include "shame!" , "Execration" , "Great hatred." , "Hatred, repugnance" , "General dislike" .)