Notice in Harlem bar: 'Goodbye, Prohibition!' (7)
I believe the answer is:
embargo
'notice' is the definition.
(notice or order restricting sales with a country)
'in harlem bar goodbye prohibition' is the wordplay.
'in' says the answer is hidden in the clue.
'EMBARGO' is hidden within 'harlem bar goodbye prohibition'.
(Other definitions for embargo that I've seen before include "Trading ban" , "Restraint - prohibition" , "Boycott" , "Official ban on trade or commerce" , "Ban or restraint on trade" .)