Novel in genuine resumption (7)
I believe the answer is:
renewal
'resumption' is the definition.
(renewing something is resuming it)
'novel in genuine' is the wordplay.
'novel' becomes 'new' (novel means new or fresh).
'in' is an insertion indicator.
'genuine' becomes 'real' (associated in meaning).
'new' inserted into 'real' is 'RENEWAL'.
(Other definitions for renewal that I've seen before include "Revitalisation" , "Fresh beginning" , "Regeneration" , "fresh start" , "Process of extending a subscription or licence" .)