Novel syllabuses lab rejected, unusually (7)
I believe the answer is:
ulysses
'novel' is the definition.
(James Joyce novel)
'syllabuses lab rejected unusually' is the wordplay.
'rejected' is a deletion indicator.
'unusually' indicates an anagram.
'syllabuses' with 'lab' removed is 'syluses'.
'syluses' with letters rearranged gives 'ULYSSES'.
(Other definitions for ulysses that I've seen before include "Wandering Greek hero or novel by James Joyce" , "Wily chap" , "-- S. Grant, US President" , "Roman name for Odysseus - famous novel" , "Famous novel by James Joyce" .)