Numb doctor upset with Friday's case (7)
I believe the answer is:
stupefy
'numb' is the definition.
(thesaurus)
'doctor upset with friday's case' is the wordplay.
'doctor' is an anagram indicator.
'with' means one lot of letters go next to another.
'case' says to hollow out the word (remove centre letters).
'friday' with its middle taken out is 'fy'.
'upset' is an anagram of 'stupe'.
'stupe'+'fy'='STUPEFY'
(Other definitions for stupefy that I've seen before include "Astound" , "Dumbfound" , "Knock out" , "Stun" , "Astonish, shock" .)