Number have tiny problem round Newcastle area (6)
I believe the answer is:
ninety
'number' is the definition.
(I know that ninety is a type of large integer)
'tiny problem round newcastle area' is the wordplay.
'problem' indicates an anagram.
'round' indicates putting letters inside.
'newcastle area' becomes 'NE' (abbreviation for North East).
'tiny' with letters rearranged gives 'nity'.
'nity' going around 'ne' is 'NINETY'.
'have' is the link.
(Other definitions for ninety that I've seen before include "nearly a ton" , "Figure in inn, yet, strangely" , "Excellent percentage score" , "Three thirties" , "Fourscore and ten" .)