Nurse accepting doctor's conclusion and direction (5)
I believe the answer is:
trend
'direction' is the definition.
(trend is a kind of direction)
'nurse accepting doctor's conclusion' is the wordplay.
'nurse' becomes 'tend' (I've seen this before).
'accepting' means one lot of letters goes inside another.
'conclusion' says to take the final letters.
The last letter of 'doctor' is 'r'.
'tend' enclosing 'r' is 'TREND'.
'and' acts as a link.
(Other definitions for trend that I've seen before include "Bias" , "Mode" , "shift" , "General direction of change" , "Leaning; fashion" .)