Nurse picking up latest in designer fashion (5)
I believe the answer is:
trend
'fashion' is the definition.
(I've seen this in another clue)
'nurse picking up latest in designer' is the wordplay.
'nurse' becomes 'tend' (tend can mean to nurse or look after).
'picking up' is an insertion indicator.
'latest in designer' becomes 'r' (I am not sure about this - if you are sure you should believe this answer much more).
'tend' going around 'r' is 'TREND'.
Can you help me to learn more?
(Other definitions for trend that I've seen before include "Leaning; fashion" , "Style, vogue" , "Tendency or fashion" , "General direction of change" , "turn" .)