Object of loathing and hate a man smashed (8)
I believe the answer is:
anathema
'object of loathing' is the definition.
(I've seen this before)
'hate a man smashed' is the wordplay.
'smashed' indicates an anagram.
'hate'+'a'+'man'='hateaman'
'hateaman' anagrammed gives 'ANATHEMA'.
'and' is the link.
(Other definitions for anathema that I've seen before include "Cursed thing" , "denunciation" , "Formal curse leading to excommunication" , "Bete noire" , "Condemned or excommunicated by church" .)