Occasionally throw-off with kick? (4)
I believe the answer is:
hoof
'kick?' is the definition.
(I've seen this before)
'occasionally throw-off' is the wordplay.
'occasionally' indicates alternate letters (letters taken at regular intervals or occasions).
'throw'+'off'='throwoff'
The alternate letters of 'throwoff' are 'HOOF'.
'with' acts as a link.
(Other definitions for hoof that I've seen before include "Ungulate's foot" , "in impromptu manner, on this" , "Foot of ungulate" , "Part of horse's foot" , "Animal foot" .)