Odd parts of theme, sacred, strangely, and profane (9)
I believe the answer is:
desecrate
'profane' is the definition.
('desecrate' can be a synonym of 'profane')
'odd parts of theme sacred strangely' is the wordplay.
'odd parts of' means one should take alternating letters.
'strangely' indicates anagramming the letters.
The alternating letters of 'theme' are 'tee'.
'tee'+'sacred'='teesacred'
'teesacred' with letters rearranged gives 'DESECRATE'.
'and' acts as a link.
(Other definitions for desecrate that I've seen before include "Profane" , "Treat (something sacred) with great disrespect" , "Secreted a means to treat something sacred with disrespect" , "Violate the sacred" , "Spoil" .)