Odd situation makes a permanent mark (5)
I believe the answer is:
stain
'a permanent mark' is the definition.
'stain' can be an answer for 'mark' (synonyms). I am not certain of the 'a permanent' bit.
'odd situation' is the wordplay.
'odd' means one should take alternating letters.
The alternating letters of 'situation' are 'STAIN'.
'makes' is the link.
Can you help me to learn more?
(Other definitions for stain that I've seen before include "Discoloured patch" , "Discolour - blemish" , "Taint" , "Discoloured mark" , "Satin (anag.)" .)