Oddly neglected house in New York making you curious (4)
I believe the answer is:
nosy
'curious' is the definition.
(similar in meaning)
'oddly neglected house in new york' is the wordplay.
'oddly neglected' means one should take alternating letters (letters in odd-numbered positions removed).
'in' means one lot of letters goes inside another.
'new york' becomes 'ny'.
The alternate letters of 'house' are 'os'.
'os' placed inside 'ny' is 'NOSY'.
'making you' is the link.
(Other definitions for nosy that I've seen before include "lots of questions" , "Intrusive in nasal way" , "Meddlesome" , "Over-inquisitive" , "Offensively curious or inquisitive" .)