Of a female, in a terrible condition (6)
I believe the answer is:
hernia
'condition' is the definition.
(hernia is a kind of condition)
'of a female in a terrible' is the wordplay.
'of a female' becomes 'her' (I've seen this before).
'terrible' indicates anagramming the letters.
'in'+'a'='ina'
'ina' is an anagram of 'nia'.
'her'+'nia'='HERNIA'
(Other definitions for hernia that I've seen before include "Protruding rupture" , "Protrusion of organ through wall of abdomen, a rupture" , "Protrusion of organ throung abdinen, rupture" , "Rupture in muscle tissue through which a structure protrudes" , "A rupture within the body" .)