Off-the-cuff remark nowadays left one blanked initially (2-3)
I believe the answer is:
ad-lib
'off-the-cuff remark' is the definition.
(I've seen this in another clue)
'nowadays left one blanked initially' is the wordplay.
'nowadays' becomes 'AD' (AD, Anno Domini, as opposed to BC, Before Christ).
'left' becomes 'l' (common abbreviation).
'one' becomes 'i' (Roman numeral).
'initially' says to take the initial letters.
The initial letter of 'blanked' is 'b'.
'ad'+'l'+'i'+'b'='AD-LIB'
(Other definitions for ad-lib that I've seen before include "Unprepared remark" , "Spontaneously" , "without restraint" , "Speak off the cuff" , "spontaneous comment" .)