Old gran played instrument (5)
I believe the answer is:
organ
'instrument' is the definition.
(I know that organ is a type of wind)
'old gran played' is the wordplay.
'old' becomes 'o' (abbreviation).
'played' indicates anagramming the letters (letters playing around).
'gran' anagrammed gives 'rgan'.
'o'+'rgan'='ORGAN'
(Other definitions for organ that I've seen before include "What makes use of full stops" , "Medium of information - most churches have one" , "House journal" , "with a lofty tone?" , "stops on one" .)