Old instrument from Early Renaissance (4)
I believe the answer is:
lyre
'old instrument' is the definition.
(I've seen this before)
'from early renaissance' is the wordplay.
'from' indicates the answer is hidden within the clue.
'LYRE' is hidden in the letters of 'early renaissance'.
(Other definitions for lyre that I've seen before include "Old instrument, like a harp" , "Ancient Greek harp" , "Type of harp" , "Ancient musical instrument - sounds mendacious" , "used to produce music" .)