Old man in agony (4)
I believe the answer is:
pain
'agony' is the definition.
(thesaurus)
'old man in' is the wordplay.
'old man' becomes 'pa' (both can mean father).
'pa'+'in'='PAIN'
(Other definitions for pain that I've seen before include "Sensation of acute discomfort" , "Tiresome figure" , "can cause discomfort" , "Suffering, distress" , "French bread?" .)