Old relative cares not for change (8)
I believe the answer is:
ancestor
'old relative' is the definition.
(relative from past generations)
'cares not for change' is the wordplay.
'for change' indicates an anagram (I've seen this in other clues).
'cares'+'not'='caresnot'
'caresnot' is an anagram of 'ANCESTOR'.
(Other definitions for ancestor that I've seen before include "Enactors (anag)" , "Forefather" , "One of one's forebears" , "one is up a tree" , "Antecedent, forebear" .)