Old Rose upsets Lola (7)
I believe the answer is:
dolores
'lola' is the definition.
(I know that lola can be written as Dolores)
'old rose upsets' is the wordplay.
'upsets' is an anagram indicator.
'old'+'rose'='oldrose'
'oldrose' anagrammed gives 'DOLORES'.
(Other definitions for dolores that I've seen before include "Lady" , "Female" , "Old sore about girl" .)