On stage in a cast giving needle (10)
I believe the answer is:
antagonise
'needle' is the definition.
(both can mean to provoke or irritate somebody)
'on stage in a cast' is the wordplay.
'cast' indicates anagramming the letters.
'on'+'stage'+'in'+'a'='onstageina'
'onstageina' with letters rearranged gives 'ANTAGONISE'.
'giving' acts as a link.
(Other definitions for antagonise that I've seen before include "anger" , "Get on the wrong side of" , "Bug" , "Arouse hostility" , "Cause opposition" .)