On the face of it, it's all over (4)
I believe the answer is:
skin
'over' is the definition.
Although both the answer and definition are singular nouns, I can't understand how one could define the other.
I don't understand the remainder of the clue.
Can you help me to learn more?
(Other definitions for skin that I've seen before include "Thin outer layer" , "Protective body covering" , "Dermis" , "Surface layer" , "External membrane of body" .)