On the loose (2,5)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">on the loose</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for at large that I've seen before include "Free to roam about, not in confinement" , "in a big way!" , "Glare at, being on the loose" , "Without particular target" , "a wild animal may roam so" .)
(Other definitions for atlarge that I've seen before include "Unrestrained" , "In general" , "as a whole" , "roaming free" .)