On the loose (2,5)
![Ross](/clue/static/ross-mug.min.png)
'on the loose' is the definition.
(synonyms)
This is all the clue.
(Other definitions for at large that I've seen before include "Free to roam about, not in confinement" , "in a big way!" , "Glare at, being on the loose" , "Without particular target" , "a wild animal may roam so" .)
(Other definitions for atlarge that I've seen before include "Unrestrained" , "In general" , "as a whole" , "roaming free" .)