On the road, he's little different from a hiker (5)
I believe the answer is:
biker
'little different from a hiker' is the definition.
I don't know anything about this answer so I can't judge whether it can be defined by this definition.
'on the road he's' is the wordplay.
'on the road' becomes 'bi' (I am not sure about this - if you are sure you should give a lot more credence to this answer).
'he' becomes 'Ker'.
'bi'+'ker'='BIKER'
Can you help me to learn more?
(Other definitions for biker that I've seen before include "Hell's Angel?" , "Motorcyclist" , "Motorcycist" , "Rider" .)