On vacation rolled joint inside - getting annoyed (7)
I believe the answer is:
rankled
'annoyed' is the definition.
(rankling is a kind of annoying)
'on vacation rolled joint inside' is the wordplay.
'on vacation' means to remove the middle letters (after the inside letters have vacated the word).
'joint' becomes 'ankle' (joint of the body).
'inside' means one lot of letters goes inside another.
'rolled' with its middle taken out is 'rd'.
'rd' going around 'ankle' is 'RANKLED'.
'getting' acts as a link.
(Other definitions for rankled that I've seen before include "Caused ongoing annoyance" , "was source of irritation" , "Annoyed" , "resented" , "Caused lasting resentment and bitterness" .)