Once again, from scratch (4)
I believe the answer is:
anew
I believe this clue is a double definition.
'once again' is the first definition.
(I've seen this in another clue)
'from scratch' is the second definition.
(I've seen this in another clue)
(Other definitions for anew that I've seen before include "Afresh" , "Once more (poetic)" , "Wane in a different way, again" , "From the beginning again" , "Again but differently" .)