One against South European wine ignoring Italy (4)
I believe the answer is:
east
'one against south' is the definition.
('south' and 'east' are opponents in bridge)
'european wine ignoring italy' is the wordplay.
'european' becomes 'E' (abbreviation e.g. EU).
'wine' becomes 'asti' (Italian wine).
'ignoring' suggests deleting specific letters.
'italy' becomes 'i'.
'asti' with 'i' removed is 'ast'.
'e'+'ast'='EAST'
(Other definitions for east that I've seen before include "Cardinal compass point" , "Bidder after North (bridge)" , "Where the sun rises" , "bridge-player" , "Oriental lands" .)