One bounding area between two American cities (5)
I believe the answer is:
nyala
'one bounding' is the definition.
(type of antelope - antelopes jump or bound)
I can't explain the rest of the clue.
(Other definitions for nyala that I've seen before include "wild animal" , "Antelope of southern Africa" , "African animal" , "South African resident" , "beast" .)