One charged with opening of night spots (4)
I believe the answer is:
acne
'spots' is the definition.
(skin condition causing spots)
'one charged with opening of night' is the wordplay.
'one' becomes 'ace' (ace has a value of one in some card games).
'charged with' means one lot of letters goes inside another (inserted letters charge into others).
'opening of' suggests taking the first letters.
The initial letter of 'night' is 'n'.
'ace' going around 'n' is 'ACNE'.
(Other definitions for acne that I've seen before include "Spotty coverage" , "Skin disorder" , "Problem to face in" , "Skin rash" , "Adolescent spots" .)