One fated, perhaps, never to know the appeal of music (4,4)
I believe the answer is:
tone deaf
'never to know the appeal of music' is the definition.
I can't judge whether this defines the answer.
'one fated perhaps' is the wordplay.
'perhaps' indicates anagramming the letters.
'one'+'fated'='onefated'
'onefated' is an anagram of 'TONE-DEAF'.
Can you help me to learn more?
(Other definitions for tone deaf that I've seen before include "insensitive to pitch" , "no ear?" , "not appreciative of notes?" .)