One hands in very skilful lab work (10)
I believe the answer is:
experiment
'lab work' is the definition.
'experiment' can be an answer for 'work' (experiment is a kind of work). I'm not sure about the 'lab' bit.
'one hands in very skilful' is the wordplay.
'one' becomes 'i' (Roman numeral).
'hands' becomes 'men' (synonyms).
'in' indicates putting letters inside.
'very skilful' becomes 'expert' (I've seen this before).
'i'+'men'='imen'
'imen' going within 'expert' is 'EXPERIMENT'.
Can you help me to learn more?
(Other definitions for experiment that I've seen before include "Trial" , "scientific investigation" , "Controlled test" .)