One has little hesitation after work to get drug (5)
I believe the answer is:
opium
'drug' is the definition.
(opium is a kind of drug)
'one has little hesitation after work' is the wordplay.
'one' becomes 'i' (Roman numeral).
'has' is a charade indicator (letters next to each other).
'little hesitation' becomes 'um'.
'after' means one lot of letters go next to another.
'work' becomes 'op' (abbreviation for opus).
'i'+'um' is 'ium'.
'ium' put after 'op' is 'OPIUM'.
'to get' is the link.
(Other definitions for opium that I've seen before include "Poppy drug" , "Addictive narcotic" , "wars with China" , "The stuff of wars" , "Number" .)