One holds husband in pain (4)
I believe the answer is:
ache
'pain' is the definition.
(ache is a kind of pain)
'one holds husband' is the wordplay.
'one' becomes 'ace' ('ace' can be a synonym of 'one').
'holds' means one lot of letters goes inside another.
'husband' becomes 'h'.
'ace' placed around 'h' is 'ACHE'.
'in' acts as a link.
(Other definitions for ache that I've seen before include "anguish" , "Feel pain" , "agony" , "Cause pain" , "Throb - hurt" .)