One left with our Sicilian wanting a hole in the head (7)
I believe the answer is:
nostril
'a hole in the head' is the definition.
(I've seen this in another clue)
'one left with our sicilian wanting' is the wordplay.
I cannot quite see how this works, but
'one' could be 'i' (Roman numeral) and 'i' is located in the answer.
'left' could be 'l' (common abbreviation) and 'l' is located in the answer.
'wanting' could be 'no' (to want is to lack or have none of something) and 'no' is found in the answer.
The remaining letters 'str' is a valid word which might be clued in a way I don't understand.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for nostril that I've seen before include "Nasal passageway" , "Part of nose" , "A hole in the head" , "Through which one would snort" , "Bit of a breather" .)