One may be in the dark when it comes to looking after people (5,5)

'it comes to looking after people' is the definition.
I don't know anything about this answer so I cannot tell whether it can be defined by this definition.

'one may be in the dark when' is the wordplay.
'one may be' becomes 'nurs' (I can't explain this - if you can you should give a lot more credence to this answer).
'in' means one lot of letters goes inside another.
'the dark' becomes 'night' (it's dark at nighttime).
'when' becomes 'e' (I've seen this in other clues).
'night'+'e'='nighte'
'nurs' put inside 'nighte' is 'NIGHT NURSE'.