One missed wandering around American city (3,6)
I believe the answer is:
des moines
'american city' is the definition.
'one missed wandering' is the wordplay.
'wandering' indicates anagramming the letters.
'one'+'missed'='onemissed'
'onemissed' with letters rearranged gives 'DES MOINES'.
'around' is the link.
(Other definitions for des moines that I've seen before include "Largest city of Iowa" , "Iowa's capital? Yes" , "Iowa's largest city" , "city on the plains" , "State capital of Iowa" .)