One new nurse is mean (6)
I believe the answer is:
intend
'mean' is the definition.
('intend' can be a synonym of 'mean')
'one new nurse' is the wordplay.
'one new' becomes 'in' (I've seen this in other clues).
'nurse' becomes 'tend' (I've seen this before).
'in'+'tend'='INTEND'
'is' acts as a link.
(Other definitions for intend that I've seen before include "Have as purpose or resolve" , "Have as one's plan" , "Signify" , "Mean; aim" , "Contemplate - mean - plan" .)