One of five content to leave cheese and fruit (6)
I believe the answer is:
quince
'fruit' is the definition.
(type of fruit)
'one of five content to leave cheese' is the wordplay.
'one of five' becomes 'quin' (short for quintuplet, one of five children).
'content to leave' means to remove the middle letters (the contents of the word are removed).
'cheese' with its centre removed is 'ce'.
'quin'+'ce'='QUINCE'
'and' acts as a link.
(Other definitions for quince that I've seen before include "Shakespearean part?" , "Cinque (anag) - fruit" , "Acidic fruit used in preserves" , "sliced fruit for newly-weds" , "part-time Athenian dramatist" .)