Crossword Genius

One small particle? In favour of 100 (6)

Ross

I believe the answer is:

proton

'one small particle?' is the definition.
(type of subatomic particle)

'in favour of 100' is the wordplay.
'in favour of' becomes 'pro' (being pro a particular cause).
'100' becomes 'ton' (ton can informally mean a hundred).
'pro'+'ton'='PROTON'

(Other definitions for proton that I've seen before include "One charged" , "Particle in atoms" , "Positive nucleon" , "Positive thing" , "Nuclear particle with positive charge" .)

I've seen this clue in The Times.
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