One uses different publication (5)
I believe the answer is:
issue
'publication' is the definition.
(I know that publication can be written as issue)
'one uses different' is the wordplay.
'one' becomes 'i' (Roman numeral).
'different' indicates an anagram (letters placed in a different order).
'uses' with letters rearranged gives 'ssue'.
'i'+'ssue'='ISSUE'
(Other definitions for issue that I've seen before include "Edition of a publication" , "Offspring; publish" , "Subject of debate" , "Bring out - children" , "Matter for discussion" .)