One visits troubled region at issue (9)
I believe the answer is:
originate
'issue' is the definition.
(I've seen this before)
'one visits troubled region at' is the wordplay.
'one' becomes 'i' (Roman numeral).
'visits' indicates putting letters inside (inserted letters visit the inside of another word).
'troubled' is an anagram indicator.
'region'+'at'='regionat'
'regionat' with letters rearranged gives 'orignate'.
'i' going into 'orignate' is 'ORIGINATE'.
(Other definitions for originate that I've seen before include "Set up" , "Arise, start" , "From kick off" , "In spring" , "Invent" .)