One who’s uncomfortable, absentee from school perhaps (1,4,3,2,5)
I believe the answer is:
a fish out of water
'one who's uncomfortable absentee' is the definition.
I know nothing about this answer so I can't tell whether it can be defined by this definition.
'from school perhaps' is the wordplay.
I cannot quite see how this works, but
'from' could be 'of' (I've seen this in other clues) and 'of' is found in the answer.
'school' could be 'fish' and 'fish' is located in the answer.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for a fish out of water that I've seen before include "one feeling out of place" , "one unsuited to situation" , "Catch" .)