One's handling female’s doubts (3)
I believe the answer is:
ifs
'doubts' is the definition.
('if' can mean a doubt or condition)
'one's handling female's' is the wordplay.
'one's' becomes 'i's' (Roman numeral).
'handling' is an insertion indicator.
'female' becomes 'f' (abbreviation).
'is' going around 'f' is 'IFS'.
(Other definitions for ifs that I've seen before include "Conditions or suppositions, may join with buts" , "Conditional conjunctions" , "Suppositions, may be accompanied by buts" , "If . . . and ands were pots and pans" , "No ...,ands or buts, no argument allowed" .)